Publications

Wilburn KM, Montague CR, Qin B, Woods AK, Love MS, McNamara CW, Schultz PG, Southard TL, Huang L, Petrassi HM, VanderVen BC. Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis. PLoS Pathog. 2022 Feb 8;18.

Rosa TLSA, Marques MAM, DeBoard Z, Hutchins K, Silva CAA, Montague CR, Yuan T, Amaral JJ, Atella GC, Rosa PS, Mattos KA, VanderVen BC, Lahiri R, Sampson NS, Brennan PJ, Belisle JT, Pessolani MCV, Berrêdo-Pinho M. Reductive Power Generated by Mycobacterium leprae Through Cholesterol Oxidation Contributes to Lipid and ATP Synthesis.  Front Cell Infect Microbiol. 2021 Jul 28;11:709972.

Aiewsakun P, Prombutara P, Siregar TAP, Laopanupong T, Kanjanasirirat P, Khumpanied T, Borwornpinyo S, Tong-Ngam P, Tubsuwan A, Srilohasin P, Chaiprasert A, Ruangchai W, Palittapongarnpim P, Prammananan T, VanderVen BC, Ponpuak M. Transcriptional response to the host cell environment of a multidrug-resistant Mycobacterium tuberculosis clonal outbreak Beijing strain reveals its pathogenic features. 2021 Science Reports Feb 4;11(1):3199.

Serafini A, Tan L, Horswell S, Howell S, Greenwood DJ, Hunt DM, Phan MD, Schembri M, Monteleone M, Montague CR, Britton W, Garza-Garcia A, Snijders AP, VanderVen B, Gutierrez MG, West NP, de Carvalho LPS Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism. 2019 Molecular Microbiology Aug 7; doi: 10.1111/mmi.14362

Fieweger RA, Wilburn KM, VanderVen BC. Comparing the Metabolic Capabilities of Bacteria in The Mycobacterium tuberculosis Complex.  2019 Microorganisms Jun 18;7(6).

Russell DG, Huang L, and VanderVen BC. Immunometabolism at the interface between macrophages and pathogens.  2019 Nature Reviews Immunology May 19(5);291-304.

Nazarova EV, Montague CR, Huang L, La T, Russell DG, and VanderVen BC.The genetic requirements of fatty acid import by Mycobacterium tuberculosis within macrophages.  2019 eLife Feb 8;8.

Wilburn KM, Fieweger RA, VanderVen BC.Cholesterol and fatty acids grease the wheels of Mycobacterium tuberculosis pathogenesis. Pathog Dis. 2018 Mar 1;76(2).

Nazarova E, Podinovskaia M, Russell DG, and VanderVen BC. Flow Cytometric Quantification of Fatty Acid Uptake by Mycobacterium tuberculosis in Macrophages. Bio-protocols. 2018 (8)4.

Clark MP, Wang T, Perola E, Deininger DD, Zuccola HJ, Jones SM, Gao H, VanderVen BC, Russell DG, Shoen CM, Cynamon MH, Thomson JA, Locher CP. 2-N-Arylthiazole inhibitors of Mycobacterium tuberculosis. Bioorg Med Chem Lett. 2017 Sep 1;27(17):3987-3991.

Nazarova E, Montague CR, La T, Wilburn KM, Lee W, Sukumar N, Caldwell S, Russell DG, and VanderVen BC. Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis. eLife. 2017. (6) pii: e26969.

Tuohetahuntila M, Molenaar MR, Spee B, Brouwers JF, Wubbolts R, Houweling M, Yan C, Du H, VanderVen BC, Vaandrager AB, Helms JB. Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation. J Biol Chem. 2017 Jul 28;292(30):12436-12448.

Johnson RM, Bai G, DeMott CM, Banavali NK, Montague CR, Moon C, Shekhtman A, VanderVen BC*, McDonough KA. Chemical activation of adenylyl cyclase Rv1625c inhibits growth of Mycobacterium tuberculosis on cholesterol and modulates intramacrophage signaling. Mol Microbiol. 2017 Jul;105(2):294-308. *co-corresponding author

Lee W, VanderVen BC, Walker S, Russell DG. 2017 Novel protein acetyltransferase, Rv2170, modulates carbon and energy metabolism in Mycobacterium tuberculosis. Science Reports. Dec 7(1)72.

VanderVen BC, Huang L, Rohde K, and Russell DG. 2016. The minimal unit of infection: Mtb in the macrophage. Microbiol Spectr. Dec 4(6).

Liu Y, Tan S, Huang L, Abramovitch RB, Rohde K, Zimmerman Z, Chen C, Dartois V, VanderVen BC, and Russell DG. 2016 Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo. J Experimental Medicine. May 2;213(5):809-25.

Lovewell RR, Sassetti CM, VanderVen BC. 2016. Chewing the fat: lipid metabolism and homeostasis during M. tuberculosis infection. Curr Opin Microbiol. Feb 29:30-6.

VanderVen BC, Fahey RJ, Lee W, Liu Y, Abramovitch RB, Memmott C, Crowe AM, Eltis LD, Perola E, Deininger DD, Wang T, Locher CP, Russell DG. 2015. Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium’s metabolism is constrained by the intracellular environment. Plos Pathogens, Feb 12 (11)2.

Russell DG, Lee W, Tan S, Sukumar N, Podinovskaia M, Fahey RJ, VanderVen BC. The Sculpting of the Mycobacterium tuberculosis Genome by Host Cell-Derived Pressures. Microbiol Spectr. 2014;2(2).

Podinovskaia M, VanderVen BC, Yates RM, Glennie S, Fullerton D, Mwandumba HC, and Russell DG. 2013. Dynamic quantitative assays of phagosomal function. Current Protocols Immunology, 102:14-34.

Lee W, VanderVen BC, and Russell, DG. 2013. Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress. J Biol Chem, 288(10):6788-6800.

Thomas ST, VanderVen BC*, Sherman DR, Russell DG, and Sampson NS. 2011. Pathway Profiling in Mycobacterium tuberculosis: Elucidation of a Cholesterol-derived Catabolite and the Enzymes that Catalyze its Metabolism. J Biol Chem, 286(51):43668-43678.*co-first author and co-corresponding author.

Mann, FM, VanderVen BC, and Peters RJ. 2011. Magnesium depletion triggers production of an immune modulating diterpenoid in Mycobacterium tuberculosis. Molecular Microbiology, 79(6):1594-15601.

Russell DG, VanderVen BC, et al. 2010. Mycobacterium tuberculosis wears what it eats. Cell Host Microbe, 8(1):68-76.

VanderVen BC, et al. 2010. Exploitation of a cell-based, chemical screen to identify inhibitors of phagosomal lipolysis. Cytometry Part A, 77A(8):751-760.

Russell DG, VanderVen BC, et al. 2009. The macrophage marches on its phagosome: Dynamic assays of phagosomal function. Nature Reviews in Immunology, 9(8):594-600.

VanderVen BC*, Yates RM, and Russell DG. 2009. Intraphagosomal measurement of the magnitude and duration of the oxidative burst. Traffic, 10(4):372-378. *corresponding author

Van de Walle GR, Peters ST, VanderVen BC, O’Callaghan DJ, and Osterrieder N. 2008. Equine herpesvirus type 1 (EHV-1) entry via endocytosis is facilitated by α-V integrins and an RSD motif in glycoprotein D. Journal of Virology, 82(23):11859-11868.

Owens RM, Hsu FF, VanderVen BC, et al. 2006. M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs). Molecular Microbiology, 60(5):1152-1163.

VanderVen BC, Harder JD, Crick DC, and Belisle JT. 2005. Export-mediated assembly of mycobacterial glycoproteins parallels eukaryotic pathways. Science, 309(5736):941-943.